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Groupe de recherche sur l'alcool et les pharmacodépendances


·      La médecine de précision en addictologie. Un besoin médical non satisfait Mickael Naassila, Wim van den Brink 2018 Alcoologie & Addictologie

·      Article de synthèse de la 1ère journée nationale de recherche en alcoologie du 13 mars 2018 à Paris organisée par l'ITMO Neurosciences - INSERM - CNRS - AVIESAN: pdf

·      Ethanol-related behaviors in alpha-synuclein mutant mice and association of SNCA SNPs with anxiety in ethanol-dependent patients. Persyn W, Houchi H, Papillon CA, Martinetti M, Antol J, Guillaumont C, Dervaux A, Naassila M.  Alcohol Clin & Exp Res. pdf

·      Unexpected effect of cyclodepsipeptides bearing a sulfonylhydrazide moiety towards histone deacetylase activity. M Létévé, C Gonzalez, G Moroy, A Martinez, J Jeanblanc, R Legastelois, M Naassila, J Sapi, E Bourguet. Bioorganic Chemistrypdf

·      Le binge drinking. Toujours aussi problématique et pas de solutions en vue, un peu de courage ! A&A  Vol. 40 No 1 (2018) PDF

·      Evaluation of alcohol use disorders pharmacotherapies in a new preclinical model of binge drinking. MC González-Marín, S Lebourgeois, J Jeanblanc, M Diouf, and M Naassila. NEUROPHARMACOLOGY télécharger le pdf ici

·      Le binge drinking. Toujours aussi problématique et pas de solutions en vue, un peu de courage ! Mickaël Naassila. Alcoologie et Addictologie. 2018 ; 40 (1) : 3-5

·      La MATE-Fr. Introduction à la version française d’un instrument d’évaluation globale en addictologie. D Galland, N Simioni, G Schippers, T Broekman, S Alaux-Cantin, H Houchi, M Naassila, B Rolland. Alcoologie et Addictologie. 2018 ; 40 (2) : 140-148.

·      Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis. Nguyen-Khac et al 6 july 2018.  The Lancet Gastroenterology & Hepatology

·      Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders. Jeanblanc J, et al. Psychopharmacology (Berl). 2018 PDF

·      A placebo controlled trial of bezafibrate in primary biliary cholangitis. Corpechot C, ..., Nguyen-Khac E, et al. New England J Med. 2018. 378(23):2171-2181.

·      [Early detection and treatment of Alcohol dependence]. Dervaux A. Presse Med. 2018 Jun;47(6):532-534. doi: 10.1016/j.lpm.2018.05.012.

·      Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease. Peineau S, et al. Pharmacol Res. 2018 PDF

·      [Epidemiology of alcohol dependence]. Laqueille X, Lacombe M, Dervaux A. Presse Med. 2018 Jun;47(6):535-546. doi: 10.1016/j.lpm.2018.04.009.

·      [Psychiatric comorbidities of Alcohol dependence]. Dervaux A, Laqueille X. Presse Med. 2018 Jun;47(6):575-585. doi: 10.1016/j.lpm.2018.01.005.

·      Influence of comorbid alcohol use disorders on the clinical patterns of major depressive disorder: A general population-based study.Carton L, et al. Drug Alcohol Depend. 2018; PDF

·      Neurobiological bases of alcohol addiction. Naassila M. Presse Med. 2018 PDF

·      Signaling lymphocytic activation molecules Slam and cancers: friends or foes? G Fouquet, I Marcq, V Debuysscher, J Bayry, AR Singh, A Bengrine, E Nguyen-Khac, M Naassila, H Bouhlal. Oncotarget 2018 

·      Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat. Lebourgeois S, Vilpoux C, Jeanblanc J, Acher F, Marie N,  Noble F, Naassila M. 2018 Neuropharmacol FI 5.012

·      GluN2B subunit of the NMDA receptor: the keystone of the effects of alcohol during neurodevelopmen. O Pierrefiche, M Naassila. 2018 Neurochem Res.

·      Class I HDAC inhibitors: Potential new epigenetic therapeutics for alcohol use disorder (AUD). Bourguet E, Ozdarska K, Moroy G, Jeanblanc J & Naassila M. 2018 J Med Chem. IF 6.25

·      Effect of N-acetylcysteine on motivation, seeking and relapse to ethanol self-administration. Lebourgeois S, González-Marín María C, Jeanblanc J, Naassila M, Vilpoux C. Addict Biol. 2018 May 30. doi: 10.1111/adb.12521 FI 4.6


2018 suite


·      What place for prolonged-release buprenorphine depot-formulation Buvidal® in the treatment arsenal of opioid dependence? Insights from the French experience on buprenorphine.Vorspan F, et al. Expert Opin Drug Deliv. 2019 PDF

·      General principles of treatment in addictology. Laqueille X, et al. Rev Prat. 2018 PDF

·      Cannabis use disorders and psychiatric comorbidities. Dervaux A. Rev Prat. 2018 PDF

·      Can artificial intelligence be used for assessing a patient with alcohol dependence? Dervaux A. Presse Med. 2018 PDF

·      Early detection and treatment of Alcohol dependence. Dervaux A. Presse Med. 2018  PDF

·      1ère journée nationale de recherche en alcoologie 2018 - pdf.
Epidemiology of alcohol dependence. Laqueille X, et al. Presse Med. 2018 PDF

·      Psychiatric comorbidities of Alcohol dependence. Dervaux A, Laqueille X. Presse Med. 2018 PDF

·      Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis. Ganne-Carrié N, et al; for CIRRAL Group. J Hepatol. 2018 PDF

·      Severe acute alcoholic hepatitis. Nguyen-Khac E, et al. Presse Med. 2018 PDF

·      Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis. Nguyen-Khac E, et al. Lancet Gastroenterol Hepatol. 2018 PDF



·      Binge eating, but not other disordered eating symptoms, is a significant contributor of binge drinking severity: findings from a cross-sectional study among French students. B Rolland,  M Naassila,  C Duffau, H Houchi,  F Gierski and J André. Frontiers in Psychology 2017.

·      Long Term Depression in Rat Hippocampus and the Effect of Ethanol during Fetal Life. Pierrefiche O. Brain Sci. 2017 Nov 28;7(12). 

·      Cloninger’s Temperament and Character Dimensions of Personality and Binge Drinking Among College Students. Gierski F, Benzerouk F, Duka T, Kaladjian A, Naassila M. 2017 Alcoholism & Clinical experimental research.

·      The Role of General Practitioners in the 2015 French Guidelines on Alcohol Misuse. B Rolland,  M Naassila,  F Paille,  H-J Aubin, On behalf of the Société Française d’Alcoologie. Alcohol and Alcoholism 2017, 

·      Synaptoimmunology - roles in health and disease. Nisticò R, Salter E, Nicolas C, Feligioni M, Mango D, Bortolotto ZA, Gressens P, Collingridge GL, Peineau S. Mol Brain. 2017 10(1):26.

·      [Epigenetic mechanisms and alcohol use disorders: a potential therapeutic target]. Legastelois R, Jeanblanc J, Vilpoux C, Bourguet E, Naassila M. Biol Aujourdhui. 2017;211(1):83-91.

·      Comparison between the WHO and NIAAA criteria for binge drinking on drinking features and alcohol-related aftermaths: Results from a cross-sectional study among eight emergency wards in France. B Rolland et al. Drug and Alcohol Dependence · March 2017

·      Binge Drinking: Current Diagnostic and Therapeutic Issues. Rolland B, Naassila M. CNS Drugs. 2017. FI 4.9

·      Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus. F. Coune, B. Silvestre de Ferron, MC Gonzalez-Marin, J. Antol, M Naassila, O. Pierrefiche. Synapse 2017 FI 2.12

·      Altered white matter integrity in whole brain and segments of corpus callosum, in young social drinkers with binge drinking pattern. KW. Smith, F Gierski, J Andre, NG. Dowell, M Cercignani, M Naassila, T Duka. 2017 Addiction Biology FI 4.6




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