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Université de Picardie Jules Verne
Groupe de recherche sur l'alcool et les pharmacodépendances

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Une communication affichée a été présentée lors du congrès de la société européenne de recherche biomédicale sur l'alcoolisme (ESBRA) à Valencia, Espagne. lien

DOES SUSCEPTIBILITY TO ALCOHOL BEHAVIORAL SENSITIZATION ALTER OPERANT SELF-ADMINISTRATION AND MOTIVATION FOR ALCOHOL?

Fabien Coune*, Maria del Carmen Gonzalez Marin*, Mickaël Naassila & Jérôme Jeanblanc

* Contributed equally to the work

INSERM ERi 24 – Research Group on Alcohol & Pharmacodependences, Université de Picardie Jules Verne, France – ANR SAMENTA SENSIBALCO 12-SAMA-008-01

Ethanol-induced behavioral sensitization (EIBS) is thought to play a role in drug taking behavior and relapse after abstinence. However, the exact role of sensitization and the vulnerability to its development in addiction phenotypes remains poorly understood. Until recently, some studies have investigated addictive behaviors in mice either prone or resistant to EIBS. Data are now available regarding the correlation between sensitization score and other phenotypes and regarding different addictive phenotypes when comparing sensitized mice and resistant mice. In this context, we have investigated to our knowledge for the first time, the operant ethanol self-administration level and the motivation to self-administer alcohol (breakpoint) depending on the vulnerability to develop sensitization: i.e. in both EIBS resistant and EIBS prone outbred Swiss mice. To induce EIBS, mice were treated once a day with 2.5 g ethanol/kg during 10 days and challenged with the same dose of ethanol 7 days later. EIBS was characterized by a significant increase in locomotion between the challenge day and day 1 and then considered as the ‘EIBS prone’ group. When the difference was not significant mice were considered as the ‘EIBS resistant’ group. Mice were then trained to self-administer 20% ethanol solution in response to one active nose poke (the other one being inactive) on a FR2 schedule. Motivation was assessed with a progressive ratio schedule. Our results show that both operant self-administration level and motivation are dependent upon the sensitization phenotype. These results confirm that EIBS vulnerability is crucial in the development of addictive behaviors.




Deux communications sous forme d'affiche ont été présentées lors du 18ème meeting annuel du réseau LARC neurosciences à Caen le 17 octobre 2014.

Is alcohol operant self-administration changed after induction of sensitization to the motor stimulant effects of alcohol? Coune F, Gonzalez Marin MC, Legastelois R, Botia B, Jeanblanc J & Naassila M.


Behavioral sensitization to ethanol: a model of alcoholism ? Legastelois R, Botia B, Coune F, Jeanblanc J & Naassila M.










Une communication sous forme d'affiche a été présenté lors du 37ème congrès de la société américaine de recherche sur l'alcoolisme (RSA) à Bellevue, USA:

IS ALCOHOL OPERANT SELF-ADMINISTRATION CHANGED AFTER INDUCTION OF SENSITIZATION TO THE MOTOR STIMULANT EFFECTS OF ALCOHOL?
By: Marin, M. C. Gonzalez; Jeanblanc, J.; Naassila, M.; et al.
Conference: 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) Location: Bellevue, WA Date: JUN 21-25, 2014
Sponsor(s): Res Soc Alcoholism; Int Soc Biomed Res Alcoholism
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 38 Special Issue: SI Supplement: 1 Pages: 240A-240A Meeting Abstract: 0959 Published: JUN 2014



Un symposium sur la sensibilisation comportementale à l'alcool a été organisé lors du dernier congrès de l'IBANGS à Louvain (20-24 mai 2013) . The International Behavioural and Neural Genetics Society (IBANGS). Ce symposium a été l'occasion de présenter les premiers résultats du projet SENSIBALCO. Les participants à ce symposium étaient notamment M. Naassila ; SL 2nd Boehm; TJ Phillips.

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Présentation d'un poster au 14ème congrès de l'ESBRA à Varsovie 8-11 septembre 2013.
ANXIETY-LIKE BEHAVIOR AND BDNF LEVELS AS MARKERS OF VULNERABILITY TO ETHANOL-INDUCED BEHAVIORAL SENSITIZATION
M. Naassila, R. Legastelois, S. Alaux-Cantin, H. Houchi and B. Botia
Abstract
Here, we focused on the characterization of predictive factor of vulnerability to develop ethanol-induced behavioral sensitization (EIBS) in mice, defined as a progressive enhancement of locomotor activity following chronic ethanol treatment and proposed as a relevant process in the initial and recurring stages of addiction. Anxiety is one of the various contributing factors that may predispose individuals to ethanol responsiveness, we thus focused on one major question: do anxiety traits influence the subsequent development of EIBS in mice? First, ethanol-naïve DBA/2J mice were submitted to anxiety-like behavioral tests. Then, during 10 days, mice were injected once daily with ethanol immediately followed by locomotor activity measurement. Mice were classified in 2-subgroups (resistant or sensitized) based on their sensitization score. A retrospective analysis highlighted a negative correlation between the sensitization score and the basal anxiety profile. Furthermore, the high-anxiety mice (resistant mice) maintained their profile all along the sensitization induction and during expression at day 17, after an ethanol challenge (“trait” anxiety). We then employed pathway focused real-time PCR arrays targeting genes involved in transduction pathways to elucidate some of the neuroadaptations underlying EIBS in both striatum and amygdala. Among the 84 genes screened, we identified putative anxiety-related genes differentially regulated between resistant and sensitized mice (crf, creb and bdnf). BDNF protein, measured by Elisa test, was correlated with basal anxiety scores. Based on basal anxiety levels, we demonstrated that anxiety predicts the propensity to develop EIBS and identified bdnf as a crucial molecular marker of this susceptibility.

Présentation d'un poster au 16ème congrès de l'ISBRA, September 9-12, 2012 Sapporo, Japan
ANXIETY-LIKE BEHAVIOR AND BDNF LEVELS AS MARKERS OF VULNERABILITY TO ETHANOL-INDUCED BEHAVIORAL SENSITIZATION
Author(s): Naassila, M.; Legastelois, R.; Alaux-Cantin, S.; et al.
Conference: 16th World Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA)Location: Sapporo, JAPANDate: SEP 09-12, 2012
Sponsor(s): Int Soc Biomed Res Alcoholism (ISBRA); Japanese Med Soc Alcohol & Drug Studies (JMSAS); Sci Council Japan
Source: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 36 Special Issue: SI Supplement: 2 Pages: 128A-128A Published: SEP 2012


Présentation d'un poster au 35ème congrès du RSA 23-27 juin 2012 San Francisco

ANXIETY-LIKE BEHAVIOR AND BDNF LEVELS AS MARKERS OF VULNERABILITY TO ETHANOL-INDUCED BEHAVIORAL SENSITIZATION
Author(s): Botia, B.; Legastelois, R.; Alaux-Cantin, S.; et al.
Conference: 35th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA)Location: San Francisco, CADate: JUN 23-27, 2012
Sponsor(s): Res Soc Alcoholism (RSA)
Source: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 36 Special Issue: SI Supplement: 1 Pages: 23A-23A Published: JUN 2012

 
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